SPECIFIC THROMBOPOIETIC INHIBITION BY SYNGENEIC PLATELET HOMOGENATES

  • 1 January 1977
    • journal article
    • research article
    • Vol. 27  (4) , 145-148
Abstract
Injections of 1-2.5 .times. 108 syngeneic, uninjured platelets did not diminish the circulating platelet count nor the bone marrow megakaryocyte content in mice, and did not influence the incorporation of 75Selenomethionine into circulating platelets. Platelet homogenates, prepared by repeated freezing and thawing of identical amounts of syngeneic platelets induced a dose-dependent thrombocytopenia along with a diminution on bone marrow megakaryocyte content, and a decrease in 75Selenomethionine incorporation. Other circulating blood cell counts were not diminished after platelet homogenates, and 3 i.v. doses of homogenates prepared from 0.7-1 .times. 105 syngeneic buffy coat cells failed to influence circulating platelet count or 75Selenomethionine incorporation.

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