Acute Pulmonary Response of Asthmatics to 3.0 PPM Formaldehyde

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Abstract
Previous studies have failed to demonstrate bronchoconstriction in unselected asthmatics after brief (≤ 1/2-h), controlled exposures to formaldehyde (HCHO). This study was designed to evaluate the acute pulmonary response to 3 ppm HCHO in nine nonsmoking asthmatic volunteers over a more relevant exposure duration (3 hrs). Pulmonary function, nonspecific airway reactivity and symp toms were assessed before and at intervals during the exposure. No significant changes in pulmonary function (FVC, FEV1 , FEF 25-27%, SGaw, or FRC) or airway reactivity were observed. There was a significant increase in nose/throat irritation at 30 min. (P < 0.05) and in eye irritation at 60 min (P < 0.05) and 180 min (P < 0.01). These results suggest that individuals with asthma will not expe rience significant bronchoconstriction when exposed at rest to 3 ppm HCHO; however, most will experience eye and upper respira tory tract irritation.