Increased Deoxycytidine Kinase Activity by Etoposide in L1210 Murine Leukemic Cells.
- 1 January 1996
- journal article
- Published by Pharmaceutical Society of Japan in Biological & Pharmaceutical Bulletin
- Vol. 19 (10) , 1382-1383
- https://doi.org/10.1248/bpb.19.1382
Abstract
Deoxycytidine kinase (dCK) is a rate-limiting enzyme for the activation of ara-C. It is responsible for the phosphorylation of ara-C which is widely used in the treatment of leukemia. We examined the effect of etoposide on dCK in L1210 cells and found that incubation with 10 microM etoposide for 1 h increased dCK activity to 170% of the control. This effect of etoposide on dCK activity was concentration-dependent up to at least 100 microM of the substance.Keywords
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