Extracorporeal perfusion of pig liver in the treatment of acute liver failure
- 1 October 1971
- journal article
- Published by Oxford University Press (OUP) in British Journal of Surgery
- Vol. 58 (10) , 746-748
- https://doi.org/10.1002/bjs.1800581009
Abstract
Five patients in deep hepatic coma due to acute liver failure were treated by perfusion of pig liver. All patients showed severe electro-encephalographic changes and 1 patient who recovered showed virtually no cerebral activity. An exchange of 48–94 litres from pig liver to patient was achieved during the procedure. All patients showed neurological improvement after perfusion. Three patients died 2 hours to 10 days after liver perfusion. The remaining 2 patients made a full recovery and are leading a normal life 9 and 14 months after perfusion.Keywords
Funding Information
- Medical Research Council
- Royal Free Hospital Endowment Fund
- Ingram Trust
- Davis Memorial Fund
- Ministry of Health development
This publication has 5 references indexed in Scilit:
- Circuitry and technique of extracorporeal porcine liver perfusion for the treatment of hepatic comaBritish Journal of Surgery, 1971
- EXTRACORPOREAL PIG-LIVER PERFUSION IN TREATMENT OF HEPATIC COMA DUE TO FULMINANT HEPATITISThe Lancet, 1971
- EFFECT OF INDUCED METABOLIC ALKALOSIS IN HEPATIC ENCEPHALOPATHYThe Lancet, 1969
- HEPATIC COMA DUE TO ACUTE HEPATIC NECROSIS TREATED BY EXCHANGE BLOOD-TRANSFUSIONThe Lancet, 1967
- Heterologous Liver Perfusion in Treatment of Hepatic FailureAnnals of Surgery, 1965