Conversion of p , p ′-DDT to p , p ′-DDD by Intestinal Flora of the Rat
- 25 March 1966
- journal article
- research article
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 151 (3717) , 1527-1528
- https://doi.org/10.1126/science.151.3717.1527
Abstract
p,p-DDD [1,1-dichloro- 2,2-bis(p-chlorophenyl)-ethane] occurs in the feces and livers of rats, that are given p, p-DDT [1,1,1-trichloro-2,2-bis-(p-chlorophenyl)-ethane] by stomach tube, but not of rats injected intraperitoneally with p,p-DDT. Coliform bacteria, isolated from feces of control animals, can effect reductive dechlorination of p,p-DDT to p,p-DDD. These findings indicate that the normal flora of the gastrointestinal tract, rather than the liver, as others have suggested, is the major source of the p,p-DDD that is found in animals fed p,p-DDT.This publication has 4 references indexed in Scilit:
- Conversion of p , p ′ DDT to p , p ′ DDD in the Liver of the RatScience, 1964
- Metabolic products of p,p′-DDT in the ratToxicology and Applied Pharmacology, 1964
- BREAKDOWN OF DDT TO DDD IN MOUSE TISSUECanadian Journal of Zoology, 1964
- Reductive Dechlorination of DDT to DDD by YeastScience, 1963