Lactone; XIII.1Phasentransfer-Oxidation nach Grignardierung: Eine einfache Synthese γ,γ-disubstituierter γ-Butyrolactone aus γ-Butyrolacton
- 1 January 1987
- journal article
- research article
- Published by Georg Thieme Verlag KG in Synthesis
- Vol. 1987 (12) , 1064-1067
- https://doi.org/10.1055/s-1987-28171
Abstract
Lactones; XIII. Grignard Reaction Followed by Phase-Transfer Oxidation: A Convenient Synthesis of γ,γ-Disubstituted γ-Butyrolactones from γ-Butyrolactone Grignard Reaction of γ-butyrolactones, followed by oxidation of the resulting reaction mixture produces symmetrically γ,γ-dialkylared diarylated γ-butyrolactones. Phase transfer oxidation with potassium permanganate in benzene/water proves to be the best out of twelve examined oxidation methods. The synthesis is unsuccessful with sterically hindered or oxidizable Grignard reagents.Keywords
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