In Vitro Antibacterial Activities of AF 3013, the Active Metabolite of Prulifloxacin, against Nosocomial and Community Italian Isolates
Open Access
- 1 December 2001
- journal article
- Published by American Society for Microbiology in Antimicrobial Agents and Chemotherapy
- Vol. 45 (12) , 3616-3622
- https://doi.org/10.1128/aac.45.12.3616-3622.2001
Abstract
AF 3013, the active metabolite of prulifloxacin, was tested to determine its inhibitory and bactericidal activities against 396 nosocomial and 258 community Italian isolates. Compared with that of ciprofloxacin, its activity (assessed in MIC and minimal bactericidal concentration tests) was generally similar or greater against gram-positive bacteria and greater against gram-negative bacteria. In time-kill assays using selected isolates, its bactericidal activity was comparable to that of ciprofloxacin.Keywords
This publication has 6 references indexed in Scilit:
- New Uses for New and Old Quinolones and the Challenge of ResistanceClinical Infectious Diseases, 2000
- Study of comparative antipneumococcal activities of penicillin G, RP 59500, erythromycin, sparfloxacin, ciprofloxacin, and vancomycin by using time-kill methodologyAntimicrobial Agents and Chemotherapy, 1994
- Pharmacokinetics and Safety of NM441, a New Quinolone, in Healthy Male VolunteersThe Journal of Clinical Pharmacology, 1994
- New quinolones and gram-positive bacteriaAntimicrobial Agents and Chemotherapy, 1994
- Antibacterial activity of NM394, the active form of prodrug NM441, a new quinoloneAntimicrobial Agents and Chemotherapy, 1993
- In vivo evaluation of NM441, a new thiazeto-quinoline derivativeAntimicrobial Agents and Chemotherapy, 1991