Skewed T cell receptor Vα repertoire among superantigen reactive murine T cells
- 1 January 1993
- journal article
- research article
- Published by Oxford University Press (OUP) in International Immunology
- Vol. 5 (1) , 55-61
- https://doi.org/10.1093/intimm/5.1.55
Abstract
Reactivity of murine T cells with viral or bacterial superantigens is clearly correlated with the expression of TCR Vβ domains. Thus, T cells responding to the minor lymphocyte stimulatory locus (Mls-1a) or staphylococcal enterotoxin B (SEB) express predominantly TCR Vβ6 or Vβ8.2 respectively. We have investigated the involvement of the other major variable element of the TCR, the Vα domain, in these superantigen responses. Using a panel of anti-TCR Vα mAbs, It is demonstrated that the TCR Vα repertoire among superantigen stimulated Vβ6+ or Vβ8.2+ blasts (responding to Mls-1a or SEB respectively in vitro) is altered in comparison with anti-CD3 stimulated cells expressing the same Vα domains. Furthermore, the TCR Vα repertoire is strongly skewed in TCR Vβ8.2 transgenic mice that have undergone extensive peripheral clonal deletion after SEB injection. These data imply that the Vα domain influences superantigen recognition by sthe TCR.Keywords
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