L6 skeletal muscle cells have functional V1‐vasopressin receptors coupled to stimulated inositol phospholipid metabolism
- 5 January 1987
- journal article
- Published by Wiley in FEBS Letters
- Vol. 210 (2) , 181-184
- https://doi.org/10.1016/0014-5793(87)81333-9
Abstract
The effects of vasopressin and related peptides upon the rat skeletal muscle cell line, L6, have been examined. No effects upon cellular cyclic AMP levels were found indicating that L6 cells possess no functional V2-vasopressin receptors. Vasopressin and its analogues did, however, stimulate the rapid and dose-dependent accumulation of inositol phosphates. This effect and the rank order of potency of vasopressin analogues demonstrate the presence of functional V1-vasopressin receptors upon L6 cells. These results suggest that the L6 line may be a useful model for vasopressin effects upon skeletal muscle metabolism.Keywords
This publication has 10 references indexed in Scilit:
- Inositol trisphosphate, a novel second messenger in cellular signal transductionNature, 1984
- A vasopressin-like peptide in the mammalian sympathetic nervous systemNature, 1984
- Relationship between inositol polyphosphate production and the increase of cytosolic free Ca2+ induced by vasopressin in isolated hepatocytes.Journal of Biological Chemistry, 1984
- Rapid breakdown of phosphatidylinositol 4-phosphate and phosphatidylinositol 4,5-bisphosphate in rat hepatocytes stimulated by vasopressin and other Ca2+-mobilizing hormonesBiochemical Journal, 1983
- Lithium amplifies agonist-dependent phosphatidylinositol responses in brain and salivary glandsBiochemical Journal, 1982
- The control of glucose 1,6-bisphosphate by developmental state and hormonal stimulation in cultured muscle tissueBiochemical Journal, 1982
- Control of hepatic glycogenolysis.Physiological Reviews, 1980
- Hormonal Stimulation of Phosphatidylinositol Breakdown, with Particular Reference to the Hepatic Effects of VasopressinBiochemical Society Transactions, 1979
- The influence of vasopressin and related peptides on glycogen phosphorylase activity and phosphatidylinositol metabolism in hepatocytesBiochemical Journal, 1979
- A simple direct assay for cyclic amp in plasma and other biological samples using an improved competitive protein binding techniqueClinica Chimica Acta; International Journal of Clinical Chemistry, 1974