The contribution of amphetamine metabolites of (?)-deprenyl to its antiparkinsonian properties
- 1 March 1982
- journal article
- research article
- Published by Springer Nature in Journal Of Neural Transmission-Parkinsons Disease and Dementia Section
- Vol. 54 (1-2) , 105-110
- https://doi.org/10.1007/bf01249283
Abstract
Although (−)-deprenyl is known to be metabolized to methamphetamine and amphetamine, two small-scale double-blind trials indicate that neither metabolite contributes to the therapeutic benefit conferred by this drug in certain patients with Parkinson's disease: the manipulation of urinary pH, which alters the rate of excretion of these metabolites, failed to change the response pattern; substitution of a metabolite mixture for active drug caused a falling off in benefit.This publication has 19 references indexed in Scilit:
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