ADHESION OF NORMAL AND SICKLE ERYTHROCYTES TO ENDOTHELIAL MONOLAYER-CULTURES

Google Scholar
  • 1 January 1979
    • journal article
    • research article
    • Vol. 54  (4) , 872-876
Abstract
The hypothesis that differences between erythrocyte surfaces from normal and sickle cell patients are reflected in the degree of attachment to the capillary lining was tested. An assay was used to measure the number of 51Cr-labeled erythrocyte (normal or sickle) attaching to an endothelial monolayer cultured from calf aortas. Under these conditions, erythrocytes from sickle cell patients adhered better to the endothelium than those from normal patients. The enhanced sickle cell adhesion to the endothelium may be partially responsible for increased blockage of capillaries that produce the symptoms in sickle cell anemia.