BIOCHEMICAL AND CLINICAL STUDIES IN RHEUMATOID ARTHRITIS DURING ADMINISTRATION OF ADRENOCORTICOTROPHIC HORMONE (ACTH)

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Abstract
A woman suffering from rheumatoid arthritis was treated with various doses of ACTH (Cortrophin, Organon). The following biochem. changes were observed during treatment: The abnormal electrophoretic pattern of the plasma proteins became normal; antistaphylolysin and streptococcus agglutination titers decreased to normal levels; the histaminolytic activity of the blood decreased; the nonspecific hyaluronidase inhibitor of the blood decreased from very high to almost normal values; and the hexosamine content of the blood decreased.