Abstract
Gastroesophageal reflux is one of the most prevalent clinical conditions affecting the gastrointestinal tract. Its spectrum ranges from the postprandial heartburn experienced at times by most adults to severe, complicated disease characterized by ulcerative esophagitis, esophageal strictures, and Barrett's esophagus (replacement of squamous epithelium with columnar epithelium) with its tendency to become malignant. Cross-sectional surveys of presumably healthy subjects in the United States have found that 7 to 10 percent have heartburn daily and 15 to 40 percent have it monthly.1 , 2 Approximately one third of the patients with heartburn who seek medical care have endoscopic evidence of esophagitis, and about . . .

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