LONG-DISTANCE LYMPHOCYTE STUDY - EFFECTS OF TRANSPORTING BLOOD ON LYMPHOCYTE BLASTOGENIC RESPONSES

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  • 1 January 1977
    • journal article
    • research article
    • Vol. 29  (1) , 168-172
Abstract
A comparison of blastogenic responsiveness to antigens and mitogen by human lymphocytes was made between cells which were processed for culture immediately following blood collection and cells obtained from blood collected 9-11 h previously and transported via commerical airline from the patients'' homes to the laboratory. There were no significant differences in the responses of transported and non-transported cells if the blood was maintained at ambient temperature during the period of shipment. Chilling the blood during transport resulted in decreased stimulation of the cells and increased background activity in unstimulated cultures. These findings indicate the feasibility of carrying out limited immunological evaluations and extended periods of follow-up for patients located at considerable distances from a research laboratory.