Frequency of RFA colour polymorphisms of human acrocentric chromosomes in Caucasians: interrelationship with QFQ polymorphisms

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Abstract
Normal Caucasians (100) were studied by sequential QFQ [Q-bands by fluorescence using quinacrine] and RFA [R-bands by fluorescence using acridine orange]. Color variants were classified into 1 of 6 colors by RFA and intensity variations into 1 of 5 levels by QFQ. There was no consistent relationship between negative or brilliant QFQ variants and the various colors observed with RFA. RFA color polymorphisms for chromosomes 13, 14, 15, 21 and 22 were 33.0, 38.0 28.0, 50.0 and 24.5%, while QFQ frequencies were 56.5, 10.0, 10.0, 15.5 and 10.0%, respectively. RFA is especially useful in studying the inheritance of chromosome 21.