Long-Term Dose-Response Effects of Vitamin E in Rats

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Abstract
In order to investigate whether and to what extent the spontaneous in vitro haemolysis test is an indicator of vitamin E nutriture, six groups of 8 male rats were kept for 22 months on diets containing 0.5, 1.5, 2.5, 4.5, 8.5 or 16.5 mg D-α-tocopheryl acetate/kg food. The severity of myopathy in the leg muscles was correlated to the vitamin E content of the diet and to the percentage of in vitro haemolysis. More than 70% haemolysis appeared to indicate a state of vitamin E deficiency, associated with severe pathological changes in the skeletal muscles. Weight gain decrease and testis degeneration occurred only at the lowest dose of vitamin E. No relation existed between mortality and the doses of vitamin E given. Complete myolysis of a muscle cell was found to be preceded by a stage of swelling, in which a strong activity of lactic dehydrogenase was observed.

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