Changes in the Length of the Neuraminidase Stalk Region Impact H7N9 Virulence in Mice
- 15 February 2016
- journal article
- Published by American Society for Microbiology in Journal of Virology
- Vol. 90 (4) , 2142-2149
- https://doi.org/10.1128/jvi.02553-15
Abstract
The neuraminidase stalk of the newly emerged H7N9 influenza virus possesses a 5-amino-acid deletion. This study focuses on characterizing the biological functions of H7N9 with varied neuraminidase stalk lengths. Results indicate that the 5-amino-acid deletion had no impact on virus infectivity or replication in vitro or in vivo compared to that of a virus with a full-length stalk, but enhanced virulence in mice was observed for H7N9 encoding a 19- to 20-amino-acid deletion, suggesting that N9 stalk length impacts virulence in mammals, as N1 stalk length does.Keywords
Funding Information
- China Ministry of Science and Technology Project 973 (2011CB504703)
- Tianjin Research Program of the Application Foundation and Advanced Technology (14JCYBJC24400)
- Influenza Virus Research of the Chinese Academy of Sciences (KJZD-EW-L09)
- Open Research Fund Program of the CAS Key Laboratory of Special Pathogens and Biosafety (2015SPCAS001)
- National Natural Science Foundation of China (81330082 31101835 81322063)
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