DNA repair synthesis in human skin exposed to ultraviolet radiation used in PUVA (psoralen and UV-A) therapy for psoriasis

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Abstract
The UV radiation used for PUVA [psoralen + long wave UV] therapy stimulated DNA repair activity in normal human skin and in the uninvolved skin from psoriatic patients. The activity detected by autoradiography increased linearly with exposure time. No stimulation was observed when the UV-B component was removed from the incident radiation by filtration through glass. Therefore UV-B damage to DNA was responsible for the activity detected following exposure to the unfiltered PUVA light source.