Mechanism of enhanced RNA synthesis in acute-phase rat liver and its relationship to chromatin structure
- 1 April 1984
- journal article
- research article
- Published by Portland Press Ltd. in Biochemical Journal
- Vol. 219 (1) , 165-171
- https://doi.org/10.1042/bj2190165
Abstract
Nuclei isolated from the liver of rats undergoing an acute inflammatory reaction induced by turpentine treatment show increased RNA synthesis. This increase is essentially determined by a faster polyribonucleotide-elongation rate while the number of transcribing polymerase molecules is unchanged. The sensitivity of chromatin to micrococcal-nuclease digestion and the composition of chromosomal proteins are not affected by the acute-phase process. Therefore the increased RNA synthesis by liver nuclei from acutely inflamed rats does not seem to correlate with major changes in chromatin structure.This publication has 29 references indexed in Scilit:
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