URINARY PROTEINS OF THE NORMAL RAT

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Abstract
The protein composition of normal male rat urine and the possible origin of its components were studied immunologically.At least sixteen antigenic components were identified, eight of which showed immunological identity to serum proteins. These are: albumin, three alpha1 (alpha1B,alphas1C,and alphas1D), two alpha2, beta2c, and gamma globulin. These components seem to arise from the blood by glomerular filtration.The other eight components did not show immunologic identity with serum proteins. Two components migrated in the rho zone, five or six in the alpha2 zone, and one in the beta zone.The antigenic relationship between tissue‐like proteins in the urine, and proteins extracted from the kidney, urinary tract or related organ tissues, was also studied. Antiserum to whole rat urine absorbed with rat serum gave two precipitin lines with kidney extract, one with the ureter, one with the bladder, three with the prostate, three with the bulbo urethral glands, two with the mixture of testis, epididymis, and ductus deferens, and two with the mixture of seminal vesicle and coagulating glands. With this same antiserum some of the tissue extracts gave reactions of identity among themselves.

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