Some aspects of lipid metabolism in rats treated with anti-insulin serum

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Abstract
In normal rats made diabetic by the injection of guinea-pig anti-insulin serum, an increase in the liver-lipid content was detected within 3 hr.; by 12 hr. the content had doubled. The concentration of free fatty acids in the serum of diabetic rats also rose rapidly, trebling in the 1st hour. The increase in liver-lipid content was due to an accumulation of neutral triglyceride, with a fatty acid composition nearly the same as that of depot fat from normal rats. This similarity supports other evidence that the accumulation of triglyceride in the livers of diabetic rats results from increased mobilization of lipid from adipose tissue.