Lactose Diets and Cholesterol Metabolism

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Abstract
Male rats were fed diets containing 40% of lactose or 1% of succinylsulfathiazole (SST) for 5 days. In two experiments hepatic cholesterol biosynthesis from acetate-1-C14 was inhibited by 69% for the lactose-fed rats and between 49 to 64% for the rats fed SST when compared with sucrose-fed controls. When mevalonic acid-δ-lactone-2-C14 was used as the liver cholesterol precursor, inhibitions of only 30 and 26% for lactose and SST-fed rats, respectively, were observed. Cholesterol biosynthesis in the small intestine from both precursors was not affected by the alterations of the diet. The magnitude of the incorporation of acetate-1-C14 into the small intestine cholesterol was over three times that observed in the liver cholesterol. In contrast, the amount of radioactive cholesterol in the liver derived from mevalonic-δ-lactone-2-C14 was ca. 19 times greater than that isolated from the intestine.