ENHANCEMENT BY BILIRUBIN OF DNA DAMAGE INDUCED IN HUMAN-CELLS EXPOSED TO PHOTOTHERAPY LIGHT
- 1 January 1984
- journal article
- research article
- Vol. 18 (1) , 3-6
Abstract
Normal human fibroblasts were exposed to light from 3 types of lamps commonly used for phototherapy treatment of neonatal hyperbilirubinemia. These irradiations were performed in either the presence or absence of exogenously added bilirubin. Each phototherapy lamp induced strand breaks in the DNA of exposed cells. The cross sections for DNA strand breakage were increased 30- to 40-fold when cells were irradiated in the presence of 100 .mu.g/ml bilirubin. Bilirubin acts as a photosensitizing agent enhancing the level of DNA damage in cells exposed to phototherapy light.This publication has 7 references indexed in Scilit:
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