Bisbenzylisoquinoline Alkaloids Inhibit Tumor Promotion by 12-O-Tetradecanoylphorbol-13-Acetate in Two-Stage Carcinogenesis in Mouse Skin
- 1 January 1993
- journal article
- research article
- Published by S. Karger AG in Oncology
- Vol. 50 (2) , 137-140
- https://doi.org/10.1159/000227165
Abstract
Bisbenzylisoquinoline alkaloids, cepharanthine, berbamine and isotetrandrine, were isolated from Stephania cepharantha Hayata. These compounds inhibit arachidonic acid-induced inflammation in mice. We have found that cepharanthine inhibits tumor promotion after topical application and oral administration in two-stage carcinogenesis in mouse skin. Furthermore, topical application of berbamine (2 μmol/mouse) and isotetrandrine (2 μmol/mouse) markedly suppressed the tumor-promoting effect of 12-O-tetradecanoylphor-bol-13-acetate (1 μg) in mouse skin initiated with 7,12-dimethylbenz[a]anthra-cene (50 μg), at a grade corresponding to that ofcepharanthine.Keywords
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