A Triamcinolone-glucose Tolerance Test in the Early Diagnosis of Diabetes

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Abstract
A glucose tolerance test with the prior administration of triamcinolone (8 mg at eleven and at one hour preceding glucose) was performed in two groups, a control group of 163 normal individuals having no diabetic antecedents; and a group of 301 "clinically prediabetic" patients so classified on obstetrical grounds or because both parents were diabetic, with a previously normal glucose tolerance test. Abnormal triamcinolone curves were found in 1.8% of the control group, an additional 1.8% were "suspicious," contrasting with 80% abnormal and 11.6% "suspicious" curves in the clinically pre-diabetic group. A comparison of this test with the standard glucose tolerance, the tolbutamide or the glucose-cortisone test, reveals that the triamcinolone test had a higher correlation with the clinical findings; also, the disadvantages attributed to the glucose-cortisone test did not occur.

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