Alterations of acyl-neuraminic acids on T-lymphocytes in cases of melanoma

Abstract
Content and distribution of the different sialic acids on human lymphocytes, isolated from 7–10 ml of fresh human blood, were determined using microanalytical methods, such as HPLC and a colorimetric test. Comparison of the data of patients with melanoma with those of healthy persons shows an evident increase of the sialic acid content combined with a shift of the sialic acid distribution to higher O-acetylated derivatives.