Amyloid β protein forms ion channels: implications for Alzheimer's disease pathophysiology
Top Cited Papers
Open Access
- 1 November 2001
- journal article
- research article
- Published by Wiley in The FASEB Journal
- Vol. 15 (13) , 2433-2444
- https://doi.org/10.1096/fj.01-0377com
Abstract
Amyloid β protein (AβP) is the major constituent of senile plaques associated with Alzheimer's disease (AD). However, its mechanistic role in AD pathogenesis is poorly understood. Globular and non-fi...Keywords
This publication has 52 references indexed in Scilit:
- Fresh and nonfibrillar amyloid β protein(1–40) induces rapid cellular degeneration in aged human fibroblasts: evidence for AβP‐channel‐mediated cellular toxicityThe FASEB Journal, 2000
- Fresh and globular amyloid β protein (1–42) induces rapid cellular degeneration: evidence for AβP channel‐mediated cellular toxicityThe FASEB Journal, 2000
- Alzheimer amyloid aβ1-42 channels: Effects of solvent, pH, and congo redJournal of Neuroscience Research, 1999
- Recognition Sequence Design for Peptidyl Modulators of β-Amyloid Aggregation and ToxicityBiochemistry, 1999
- Alzheimer's diseaseNeurology, 1998
- Dendritic changes in Alzheimer's disease and factors that may underlie these changesProgress in Neurobiology, 1998
- Cellular actions of beta-amyloid precursor protein and its soluble and fibrillogenic derivativesPhysiological Reviews, 1997
- Zn2+ interaction with Alzheimer amyloid beta protein calcium channels.Proceedings of the National Academy of Sciences, 1996
- Giant multilevel cation channels formed by Alzheimer disease amyloid beta-protein [A beta P-(1-40)] in bilayer membranes.Proceedings of the National Academy of Sciences, 1993
- Seeding “one-dimensional crystallization” of amyloid: A pathogenic mechanism in Alzheimer's disease and scrapie?Cell, 1993