Ribozyme catalysis: not different, just worse
- 3 May 2005
- journal article
- review article
- Published by Springer Nature in Nature Structural & Molecular Biology
- Vol. 12 (5) , 395-402
- https://doi.org/10.1038/nsmb932
Abstract
Evolution has resoundingly favored protein enzymes over RNA-based catalysts, yet ribozymes occupy important niches in modern cell biology that include the starring role in catalysis of protein synthesis on the ribosome. Recent results from structural and biochemical studies show that natural ribozymes use an impressive range of catalytic mechanisms, beyond metalloenzyme chemistry and analogous to more chemically diverse protein enzymes. These findings make it increasingly possible to compare details of RNA- and protein-based catalysis.Keywords
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