Über Gewinnung und Abbau des Cytohämins

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Abstract
The extraction and crystallization of cytohemin from horse hearts, its decomposition into cytodeuteroporphyrin and of the latter into hematinic acid and methylmaleinimide are described. According to spectral and elementary analysis, cytodeuteroporphyrin was not distinguishable from protodeuteroporphyrin. From the melting points of the dimethylesters, however, it was evident that the 2 prophyrins are different. This result was confirmed by the fact that the cytodeuteroporphyrin on bromina-tion takes up 3 atoms of bromine while protodeuteroporphyrin takes up only 2 atoms. Cytodeuteroporphyrin, accordingly, appears to have 3 free positions. Two pyrromethenes were prepared, 4,5,5-trimethyl-pyrromethene and 4,5,5-trimethyl-4-ethylpyrromethene which served for the preparation of 2 new deuteroporphyrins. Tables of the melting points (m.p.) of several deuteroporphyrindimethylesters and their bromine derivatives and the m.p.''s of 4 new deuteroporphyrins are given.

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