Measuring intraepithelial lymphocytes, surface area, and volume of lamina propria in the jejunal mucosa of coeliac patients.
Open Access
- 1 April 1979
- Vol. 20 (4) , 275-278
- https://doi.org/10.1136/gut.20.4.275
Abstract
An accurate morphometric method is described for quantifying the intraepithelial lymphocytes (IEL), the area of the epithelium, and the volume of the lamina propria in jejunal mucosa of coeliac patients. All measurements are related to a unit-length of muscularis mucosa which is unaltered by the disease process. The results show a significant decrease in the epithelial surface area and an increase in the volume of the lamina propria in coeliac jejunal mucosa compared with normal levels, even after treatment. The number of IEL is the same as normal before or after treatment. Other workers have shown an apparent increase in IEL in untreated disease which returns to normal levels after therapy. This discordance is explained and the importance of accurate quantitative methodology is stressed.This publication has 6 references indexed in Scilit:
- Intraepithelial lymphocytes of the small intestine.Gut, 1977
- Cellular infiltrate of the jejunum after re-introduction of dietary gluten in children with treated coeliac disease.Journal of Clinical Pathology, 1976
- Cellular infiltrate of jejunal biopsies in adult coeliac disease in relation to gluten withdrawalGut, 1974
- The Interepithelial Lymphocytes of the Intestinum. Morphological Observations and Immunologic Aspects of Intestinal EnteropathyPublished by Springer Nature ,1973
- Quantitation of intraepithelial lymphocytes in human jejunumGut, 1971