Endothelium Function Is Protected by Albumin and Flow-Induced Constriction Is Independent of Endothelium and Tone in Isolated Rabbit Femoral Artery
- 1 January 1992
- journal article
- research article
- Published by S. Karger AG in Journal of Vascular Research
- Vol. 29 (5) , 367-375
- https://doi.org/10.1159/000158953
Abstract
To investigate the preservation of endothelial function, we perfused two segments of one rabbit femoral artery (n = 8) in a pressure myograph in parallel, both with Tyrode, but one with 0.6% albumin added. The change in the outer diameter of the vessels [preconstricted with norepinephrine (NE) to 70%] in response to acetylcholine as an indicator of the endothelial function, was repeatedly measured over 5 h after the equilibration. The difference between the acetylcholine responses of the two vessel segments was significant (p&Keywords
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