An Approach to the Numerical Quantitation of Acute Tissue Response to Biomaterials
- 1 January 1975
- journal article
- Published by Taylor & Francis in Biomaterials, Medical Devices, and Artificial Organs
- Vol. 3 (1) , 47-56
- https://doi.org/10.3109/10731197509118613
Abstract
The hydrolytic enzyme activity associated with the tissue reaction to implanted polyvinyl chloride rods containing graded concentrations of an organotin stabilizer was quantitated by microphotometry of tissue sections. The procedure was more sensitive to the effects of the additive than the usual histologic evaluation. It is considered that this type of approach offers a sensitive and objective index to supplement the more subjective morphologic observations in judging the acute histotoxicity of implants.Keywords
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