The Effect of Etiocholanolone on Granulocyte Kinetics

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Abstract
The effect of etiocholanolone on granulocyte kinetics in 12 hematologically normal patients has been investigated using the technic of 3H-DFP labeling of autologous blood in vitro. Baseline determinations of the total blood granulocyte pool (TBGP), the circulating pool (CGP), and the marginated pool (MGP) were performed. The values for the total blood granulocyte pools were similar to those previously reported. Following the administration of etiocholanolone, there was a 98 per cent increase in the TBGP, which was considered to be due to mobilization of granulocytes from the bone marrow reserve. There was no change in the ratio of CGP to MGP. These studies suggest that etiocholanolone may be a useful agent for the estimation of bone marrow reserve.