Use of Pharmacogenetic and Clinical Factors to Predict the Therapeutic Dose of Warfarin
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- 27 February 2008
- journal article
- Published by Wiley in Clinical Pharmacology & Therapeutics
- Vol. 84 (3) , 326-331
- https://doi.org/10.1038/clpt.2008.10
Abstract
Initiation of warfarin therapy using trial‐and‐error dosing is problematic. Our goal was to develop and validate a pharmacogenetic algorithm. In the derivation cohort of 1,015 participants, the indep...Keywords
This publication has 40 references indexed in Scilit:
- Randomized Trial of Genotype-Guided Versus Standard Warfarin Dosing in Patients Initiating Oral AnticoagulationCirculation, 2007
- Genetic-based dosing in orthopedic patients beginning warfarin therapyBlood, 2007
- Population variation in VKORC1 haplotype structureJournal of Thrombosis and Haemostasis, 2006
- The influence of sequence variations in factor VII, γ-glutamyl carboxylase and vitamin K epoxide reductase complex genes on warfarin dose requirementThrombosis and Haemostasis, 2006
- Functional Characterization of Novel Allelic Variants of CYP2C9 Recently Discovered in Southeast AsiansThe Journal of Pharmacology and Experimental Therapeutics, 2005
- Effect ofVKORC1Haplotypes on Transcriptional Regulation and Warfarin DoseNew England Journal of Medicine, 2005
- Prospective dosing of warfarin based on cytochrome P-450 2C9 genotypeThrombosis and Haemostasis, 2005
- Use of pharmacogenetics and clinical factors to predict the maintenance dose of warfarinThrombosis and Haemostasis, 2004
- Initiating and Maintaining Patients on Warfarin Anticoagulation: The Importance of MonitoringJournal of Cardiovascular Pharmacology and Therapeutics, 1999
- Association of polymorphisms in the cytochrome P450 CYP2C9 with warfarin dose requirement and risk of bleeding complicationsThe Lancet, 1999