The biliary metabolism of butylated hydroxytoluene (3, 5-di-t-butyl-4-hydroxy-toluene) and its derivatives in the rat
- 1 November 1970
- journal article
- Published by Oxford University Press (OUP) in Journal of Pharmacy and Pharmacology
- Vol. 22 (11) , 832-838
- https://doi.org/10.1111/j.2042-7158.1970.tb08448.x
Abstract
The biliary metabolism of 3, 5-di-t-butyl-4-hydroxybenzyl alcohol (BHT-CH2OH), 3, 5-di-t-butyl-4-hydroxybenzaldehyde (BHT-CHO) and 3, 5-di-t-butyl-4-hydroxybenzoic acid (BHT-COOH) after parenteral administration has been examined in the rat and compared to that of 3, 5-di-t-butyl-4-hydroxytoluene. Quantitative excretion and chemical examination of bile showed that in the enterohepatic circulation BHT-COOH or its ester glucuronide is the recirculating compound from the four compounds studied. Biliary excretion data are also presented for 1, 2-bis(3, 5-di-t-butyl-4-hydroxyphenyl)ethane.Keywords
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