Cytolytic T cell hybridomas II. Interleukin 2-independent cytolytic variants

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Abstract
Interleukin 2 (IL 2)-dependent cytolytic hybrids usually loose IL 2 dependence and cytolytic activity concomittantly. Here we describe an exceptional IL 2-independent variant which lost IL2 receptor but retained cytolytic activity. When the IL 2-independent cytolytic hybrid cells were fused with IL 2-dependent cytolytic clones which express IL2 receptors constitutively, IL 2-dependent hybrids were obtained. This suggests that the expression of IL 2 receptors can interfere with IL 2-independent growth mechanisms.