Synthetic Studies of Halichondrin B, an Antitumor Polyether Macrolide Isolated from a Marine Sponge. 1. Stereoselective Synthesis of the C1-C13 FragmentviaConstruction of the B and A Rings by Kinetically and thermodynamically Controlled Intramolecular Michael Reactions.
- 1 January 1994
- journal article
- letter
- Published by Georg Thieme Verlag KG in Synlett
- Vol. 1994 (01) , 38-40
- https://doi.org/10.1055/s-1994-22730
Abstract
A stereoselective synthesis of the C1-C13 fragment of halichondrin B starting from D-glucose is reported. Construction of 2,5-trans (B) and 2,5-cis substituted tetrahydropyran (A) rings using intramolecular Michael reactions under kinetical and thermodynamical conditions, respectively, were the critical steps.Keywords
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