SINGLE-CELL DNA MEASUREMENTS IN HYPERPLASTIC, DYSPLASTIC AND CARCINOMATOUS LARYNGEAL EPITHELIA, WITH SPECIAL REFERENCE TO THE OCCURRENCE OF HYPERTETRAPLOID CELL-NUCLEI

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  • 1 January 1983
    • journal article
    • research article
    • Vol. 5  (3) , 184-188
Abstract
Single-cell DNA fluorometry was performed on smear preparations from 57 histologically verified lesions from human vocal cords. Special attention was paid to the detection of hypertetraploid cell nuclei, which may be considered neoplastic markers, since they are not present in normal vocal cord epithelium. Hypertetraploid nuclei were not found in hyperplastic or mildly dysplastic epithelia but were found in 4 of 14 specimens of moderate dysplasia and in 5 of 19 specimens of severe dysplasia. The presence of hypertetraploid nuclei was associated with more frequent recurrences and progression of disease. Hypertetraploid cell nuclei were found in 9 of 15 invasive carcinomas and in this group were associated with a worse prognosis. The proliferative activity was 1.7% for hyperplasia and mild dysplasia, 3.1 % and 2.8%, respectively, for moderate and severe dysplasia and 7.6for squamous-cell carcinoma.