The effects of prostaglandin and mating on release of LH in the female rabbit

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Abstract
The release of LH [luteinizing hormone] in response to prostaglandin (PG) treatment of female rabbits in various reproductive states was compared with the surge following mating. Intracarotid infusion of PGE-2 or PGF-2.alpha. (0.3-900 .mu.g/h) into non-receptive and pseudopregnant does resulted in small, 2-4-fold elevations in jugular vein LH concentration. Similar doses of PGF-2.alpha. in estrogen-pretreated, estrous does stimulated a 13-fold increase in plasma LH levels. Mating resulted in a much larger release of LH, as plasma levels increased approximately 60-fold from 1.1 .+-. 0.2 (SEM [standard error of the mean]) ng/ml to 67.8 .+-. 10.5 ng/ml. PG can stimulate the hypothalamic-hypophysial axis to release LH in non-receptive, pseudopregnant and estrogen-pretreated, estrous rabbits.