ALKALOIDS OF THALICTRUM .22. ISOLATION OF ALKALOIDS WITH HYPOTENSIVE AND ANTIMICROBIAL ACTIVITY FROM THALICTRUM-REVOLUTUM

  • 1 January 1977
    • journal article
    • research article
    • Vol. 40  (5) , 508-514
Abstract
Alkaloids (16) were characterized from T. revolutum, namely; thalidasine, O-methylthalmethine, O-methylthalicberine, thalrugosaminine, thalicarpine, thalmelatine, pennsylvanine, thaliglucinone, palmatine, berberine, thalifendine, columbamine, jatrorrhizine, deoxythalidastine, thalphenine and magnoflorine. The structure of thalrugosaminine, a bisbenzylisoquinoline type which was previously proposed on partial data, was completely established including the absolute configuration as S,S. Thalphenine, thalidasine, O-methylthalicberine, thalicarpine, thalrugosaminine and thaliglucinone possessed hypotensive activity in rabbits. Thalrugosaminine, thalicarpine, thalmelatine, O-methylthalmethine, pennsylvanine and thalphenine were active against Mycobacterium smegmatis.