A General Regression Procedure for Method Transformation. Application of Linear Regression Procedures for Method Comparison Studies in Clinical Chemistry, Part III

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Abstract
The biometrical treatment of laboratory data may require the estimation of a regression line for the transformation of one set of measurments to another. The regression procedure introduced in part I (1) of our work does not always yield unbiased results in such situations, since its estimators are not scale invariant. In part III we present the parameter estimation of a general regression equation which is scaleinvariant and retains all properties of the method comparison procedure, in particular it robustness. Its application is demonstrated by several examples, and the results are compared with other robust biometrical procesures. The mathematical aspects are explained in the appendix.