Cloning of the inhibin/activin βB subunit gene from the Booroola Merino sheep
- 1 February 1991
- journal article
- Published by Bioscientifica in Journal of Molecular Endocrinology
- Vol. 6 (1) , 87-93
- https://doi.org/10.1677/jme.0.0060087
Abstract
The gene encoding the inhibin/activin βB subunit was isolated from a Booroola Merino ewe which had two copies of the unidentified fertility gene. Both the DNA sequence (>87%) and amino acid sequence (>93%) were highly homologous to those of the human and rat genes. The upstream region of the gene was similar to that of the human and rat genes, having SP1 binding sites and no TATA or CAAT boxes and, like that of the rat, but unlike that of the human gene, no cyclic AMP response elements, suggesting that the βB gene of sheep and rats is regulated differently from that of man.Keywords
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