Antipsychotic effects of lithium in schizophrenia

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Abstract
The Li2CO3 therapy of 13 psychotic schizophrenic patients was evaluated in a placebo-controlled 3-wk study that was double-blind. Seven of the 13 patients were less psychotic while receiving Li; 4 of these 7 patients relapsed after Li withdrawal. Patients who improved during the 3rd wk on Li could be differentiated from nonresponders on the basis of their improvement during the 1st wk. Clinical factors such as diagnosis, prognosis, and symptoms failed to predict responders from nonresponders. This is apparently the first controlled study to yield positive results with schizophrenic patients treated with Li alone.

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