DISCRIMINATION OF NARCOTIC DRUGS ON FENTANYL-H-3 RECEPTOR-BINDING

  • 1 January 1976
    • journal article
    • research article
    • Vol. 220  (2) , 335-338
Abstract
Stereospecific opiate receptor binding was measured using specifically labeled fentanyl in the presence of an excess of either dextromoramide or levomoramide, only the former being the analgesic isomer. In a large series of chemically related drugs with differing pharmacological activity, it was possible to recognize compounds endowed with a potential morphine-like activity. Attempts were made to localize the opiate receptors within the neuronal cell in rat brain.

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