PROLIFERATION OF RENAL INTERSTITIAL-CELLS FOLLOWING INJURY INDUCED BY URETERAL OBSTRUCTION

  • 1 January 1976
    • journal article
    • research article
    • Vol. 35  (1) , 18-22
Abstract
The proliferation of renal interstitial cells was studied by the use of [3H]-thymidine incorporation following unilateral ureteral obstruction in the rabbit. There was a nonuniform response with significant increase in nuclear labeling in the obstructed kidney in all zones at 24, 48, and 72 h following obstruction with the exception of the inner medulla where the counts at 24 and 48 h were not significantly different from sham-operated controls. The major labeling occurred in interstitial fibroblasts. Within the zones of high labeling (cortex and outer medulla) these cells were separated by widening of the interstitial space. In the zone of low labeling (inner medulla) the interstitial cells maintained their normal spatial relationships.

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