The Quantitation of Hemorrhage in the Skin. Measurement of Hemorrhage in the Microcirculation in Inflammatory Lesions and Related Phenomena

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Abstract
Cutaneous hemorrhage was quantitated using 59Fe-labeled red blood cells. The red blood cells were labeled by injecting 59Fe-ferrous citrate preincubated with serum. Skin lesions were induced in rabbits whose own red cells were labeled or in animals which were transfused with labeled cells. Hemorrhagic lesions were produced by injecting heat- or formalin-killed Escherichia coli, lysates of human PMN[polymorphonuclear]-leukocyte lysosomes, trypsin or by eliciting the local Shwartzman reaction.