Prostaglandin-E1 in the pre-operative management for pulmonary atresia.

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Abstract
During 1971-1976, 7 patients with pulmonary atresia or pseudotruncus arteriosus had undergone various shunt operations at Tohoku University Hospital; the survival rate was 29%. There were difficulties in the pre- and postoperative management of the cases due to their deteriorated life conditions caused by PDA [patent ductus arteriosus] closure before the operation. Since the summer of 1976, 8 other cases of such anomalies were seen; 5 of them were given prostaglandin[PG]E1 as a non-surgical palliation before the shunt operation. PGE1, 0.01-0.1 .mu.g/kg per min, was given i.v. with a micro-drip technique. The administration was followed by immediate and significant rise in Pa[arterial partial pressure]O2 and Sa[arterial saturation]O2. As a side effect, periodic apnea was observed. Respiratory management is indispensable in using PGE1. The technique seems to be an effective treatment as a nonsurgical palliation for such patients.