Leiomyosarcoma of the Kidney. Immunohistological and Ultrastructural Findings with Special Emphasis on the Growth Fraction

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Abstract
This report deals with a case of renal smooth muscle tumour. Considering the low mitotic rate, this reoplasm would have been classified as leiomyoma. However, it displayed a relatively large growth fraction by immunostaining with the monoclonal antibody Ki-67. This led us to the diagnosis "leiomyosarcoma", which is in line with the unfavourable clinical course. We suggest that assessment of the growth fraction with Ki-67 seems to be more objective than the conventional criteria for determining the malignant potential of smooth muscle tumours.