STUDIES IN ASTHMA

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Abstract
That vasomotor rhinitis and bronchospasm, as they occur in man, are in most instances manifestations of hypersensitiveness to some foreign substance has been recognized since 1906, when Wolff-Eisner1suggested the allergic nature of hay-fever, and 1910, when Meltzer2pointed out the possibility that bronchial asthma was a manifestation of anaphylaxis in man. Since then, different observers have reported instances of such varied symptoms as eczema,3migraine,4certain gastro-intestinal disturbances,5epilepsy,6and kidney and bladder pain7as being other manifestations of allergy. These contributions have opened new possibilities for the proper interpretation and better understanding of certain obscure symptom complexes in man. It is singular that cough, which often accompanies vasomotor rhinitis as well as bronchospasm, has always been considered secondary to these conditions and never as an independent symptom of allergy. In a recent communication one of us8described a case in

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