Powerful hepatoprotective and hepatotoxic plant oligostilbenes, isolated from the Oriental medicinal plantVitis coignetiae (Vitaceae)

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Abstract
The methanol extract of the Oriental medicinal plantVitis coignetiae (Vitaceae) showed hepatoprotective activity in the in vitro assay method using primary cultured rat hepatocytes. Activity-guided fractionation of the extract afforded ɛ-viniferin as an active principle. The protective effect of ɛ-viniferin against mice carbon tetrachloride-induced hepatic injury in mice was shown by serum enzyme assay as well as by pathological examination. In addition to ɛ-viniferin, plant oligostilbenes, ampelopsins A, C, F and the mixture of vitisin A andcis-vitisin A were also present in the extract. Among them, ampelopsin C and the mixture of vitisin A andcis-vitisin A were found to be powerful hepatotoxins.